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Yüksek plazma Lp (a) konsantrasyonu ile aterosklriotik damar hastaliklari gelişimi arasindaki ilişkiyi gösteren epiderniyolojik kanit­ lar ve yakin zamanda yapilan biyokimyasal çalişmalar, plazma Lp (a) konsantrasyonlarinin düşürülmesinde büyük bir ilgi uyandirmiştir. Bu makalenin amaci, plazma Lp (a) konsantrasyonlarini güvenli düzeylere indirmede kullanilacak araçlarin tesbitiyle ilgili çalişmalari gözden geçirerek tartişmaktir. Anahtar kelimeler: Diyet, Farmakolojik ajanlar, Aferez, Lipopro­ tein (a) SUMMARY The epidemiological evidence and the recent biochemical studies which show association between elevated plasma concentrations of lipoprotein (a) (Lp (a)) and the development of atherosclerot ic vascular disease, have stimulated a great deal of interest in lowering plasma Lp (a) concentrations. The aim of this paper is to rewiev and discuss the studies in identifying means for bringing plasma Lp (a) concentrations down to safe levels.

ankara üniversitesi eczacılık fakültesi dergisi

Diyet, Farmakolojik Ajanlar ve Aferez Uygulamalarının Plasma Lipoprotein (a) Düzeyleri Üzerindeki Etkileri : The Effects of Diet, Pharmacological Agents and Apheresis Procedures on Plasma Levels of Li