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In adenine-administered rats, urine volume increased gradually with the progress of renal dysfunction to polyuria, but the amounts of urea, creatinine (Cr), guanidinosuccinic acid (GSA) and guanidinoacetic acid (GAA) excreted into the urine showed a significant decrease throughout the experimental period. In contrast, excretion of methylguanidine (MG) was markedly increased. The glomerular filtration rate (GFR), renal plasma flow (RPF) and renal blood flow (RBF) decreased progressively as the renal impairment increased due to prolonged administration of adenine.

Urinary constituents and renal function in rats administered with adenine.