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A decreased cardiac (123)I-metaiodobenzylguanidine ((123)I-MIBG) uptake has been used as a powerful tool to identify Lewy body disease, such as idiopathic parkinson's disease (IPD). We performed cardiac (123)I-MIBG scintigraphy in patient with autosomal recessive juvenile parkinsonism (ARJP) with parkin gene mutation (PARK2). The findings showed normal cardiac (123)I-MIBG uptake. Therefore, although the clinical features of ARJP are sometimes quite similar to those of late-onset IPD, cardiac (123)I-MIBG scintigraphy may be used as a valuable tool to identify patients with IPD and to distinguish them from patients with other parkinsonian syndromes.

journal of movement disorders

Cardiac &amp;lt;sup&amp;gt;123&amp;lt;/sup&amp;gt;I-metaiodobenzylguanidine Scintigraphy in a Patient with Familial Parkinsonism with &amp;lt;italic&amp;gt;Parkin&amp;lt;/italic&amp;gt; Gene Mutation