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The calcium ion (Ca 2+ ) is a key intracellular signaling molecule with far-reaching effects on many cellular processes. One of the most important such Ca 2+ regulated processes is transcription. A body of literature describes the effect of Ca 2+ signaling on transcription initiation as occurring mainly through activation of gene-specific transcription factors by Ca 2+ -induced signaling cascades. However, the reach of Ca 2+ extends far beyond the first step of transcription. In fact, Ca 2+ can regulate all phases of transcription, with additional effects on transcription-associated events such as alternative splicing. Importantly, Ca 2+ signaling mediates reduced transcription termination in response to certain stress conditions. This reduction allows readthrough transcription, generating a highly inducible and diverse class of downstream of gene containing transcripts (DoGs) that we have recently described.

Calcium signaling and transcription: elongation, DoGs, and eRNAs