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Lung cancer is the leading cause of cancer─related death. Recently, the incidence of lung cancer, especially for elderly patients, has been increasing in Japan . Over 60% of patients are treated with chemotherapy because of their advanced stages at the time of diagnosis. Recent progress in chemotherapy has significantly prolonged the survival of elderly patients with advanced lung cancer compared to best supportive care . However, not only their survival benefit, but also their quality of life (QOL) during treatment needs to be considered when treatment efficacy is evaluated. In fact, QOL was used as the primary endpoint in the Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) trial and the secondary endpoint in various clinical studies for elderly patients with lung cancer . QOL prior to chemotherapy has been reported to be a useful surrogate marker for the prediction of prognosis . However, there are few reports focusing on the effect of continuation of chemotherapy on the QOL of elderly patients with lung cancer . The aim of this study was to clarify the QOL profiles in elderly patients during chemotherapy in comparison with that in younger patients.

Effect of Continuation of Chemotherapy on Quality of Life in Elderly Patients with Lung Cancer -Comparison with That in Younger Patients -