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AIM: The present study aimed to elucidate the influence of thymus peptides thymulin, thymosin alpha 1 and thymosin beta 4 applied s.c. on intact rats, on key triggering factors of blood coagulation via the extrinsic pathway: plasma concentration of tissue factor (TF); concentration and activity of free TFPI; and the activity of plasma clotting factor VII, as well as on prothrombin time (PT) – an integral clinical parameter of the intrinsic pathway.

scripta scientifica medica

Significant inhibition of the triggering mechanism of the extrinsic system of blood coagulation in rats by thymus peptides thymulin, thymosin alpha 1 and thymosin beta 4