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INTRODUCTION : Studies have established oxidative disorders in persistent and permanent atrial fibril- lation. Our aim was to investigate oxidative status still in the early hours of paroxysmal atrial fibrillation (PAF) and monitor its changes after sinus rhythm (SR) restoration. MATERIAL AND METHODS : Levels of malondialdehyde and total glutathione were determined in plas- ma (Pl-MDA; Pl-GSH) and erythrocytes (Er-MDA; Er-GSH) together with erythrocyte glutathione perox- idase activity (GSH-Px) in 51 patients (59.84±1.6 years, 26 males). Markers were investigated upon hospi- tal admission, 24 hours and 28 days after SR restoration. They were also determined in 52 healthy subjects (59.50±1.46 years, 26 males). RESULTS : Mean AF duration prior to hospitalization was 8.14±0.76 hours. Upon admission, Pl-MDA and Er-MDA were significantly increased (p 0.05).

Dynamics of oxidative status in patients with paroxysmal atrial fibrillation