English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

PURPOSE: Extensive sets of simulations are realized in this paper to gain insight into the problems of impulse propagation in temperature dependent motor nerve axons. The effect of temperature on the impulse threshold currents and action potential parameters (velocity, amplitude) is shown in simulated mammalian (rabbit) and human motor nerve fibres. MATERIAL AND METHODS: Using our multi-layered model of human motor nerve fibre, temperature coefficients Q10's are involved for the conductivities of axoplasm, periaxonal space and for ionic currents (nodal and internodal). The standard temperature for our model is 37oC. The temperature increases from 20o to 60oC. RESULTS: The essential and very important result is that the simulated conduction block at 48o and 45oC in the rabbit and human motor nerve axons, respectively, is extremely sensitive to the rate constants of nodal sodium (PNA), fast potassium (PKf) and slow (PKs) potassium maximum permeabilities. The temperature dependence of conduction velocity over a range of 20-42oC and 20-40oC for the rabbit and human motor nerve axons, respectively, is not linear or exponential. Due to this, a polynomial function of degree 2 (transfer standard parabola), which relates velocity to temperature, provides an accurate fit of the data. CONCLUSION: Our modified multi-layered model used in this study is first ever in which the simulated temperature dependent velocities and conduction block in the rabbit and human motor axons are in good agreement with the experimental values. Scripta Scientifica Medica 2013; 45(3): 36-41.

Modified multi-layered model of temperature dependent motor nerve axons