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PURPOSE: The objective of the present study was to determine the effectiveness of esomeprazole-based sequential therapy and Bio Gaya probiotic for the treatment of Helicobacter pylori-infection (Hp-infection) with associated gastro duodenal diseases. MATERIAL AND METHODS: The study covered 104 patients with dominating upper dyspeptic syndrome and Hp-infection examined by means of two or more methods. Esomeprazole-based sequential therapy consisted in amoxicillin in a dose of 1.0 g two times daily for the first five days followed by clarithromycin and metronidazole in a dose of 500 mg two times daily for the next 5 days. A Bio Gaya probiotic was added during the 10-day treatment. RESULTS: Hp-infection was successfully treated in 98 patients (94.2%) and in 79 out of 81 naive ones (97% of the cases). This therapy proved effective in 19 out of 23 patients (82.6%) after one or two failed Hp-infection eradications, too. The treatment failed in 6 patients (5.7%) because of a double antibiotic resistance. CONCLUSION: The esomeprazole-based sequential therapy and Bio Gaya probiotic represented a highly and well-tolerable effective eradication option. Clinical symptoms and quality of life were favourable influenced in all the patients as well as side effects were rare. Scripta Scientifica Medica 2013; 45(2): 61-65.

Esomeprazole-based sequential therapy and probiotic for Helicobacter pylori eradication