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Intercellular communication plays an essential role in the (patho)physiological function of the adipose tissue. (Pre)adipocyte-secreted proteins, collectively known as adipokines, serve as signaling molecules in a paracrine and endocrine fashion. Adipokine profiles are dynamic and can change dramatically leading to metabolic complications during obesity or can return towards a more beneficial profile under influence of weight loss interventions. Here it is reviewed how proteomics technologies contributed to identify (pre)adipocyte-secreted proteins. Different secretion routes are highlighted with a particular focus on microvesicle-mediated secretion. Furthermore, novel information is provided on identification of human adipokines and on the application of proteomics technologies to discover unknown adipokine-receptor interactions. Adipobiology 2012; 4: 33-40.

The role of proteomics research in discovering adipocyte-secreted proteins and their (patho)physiological role