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Sepsis, due to multiorgan failure,[1,2] causes death in intensive care units as high as 20% worldwide[3–5] because mortality rates are extremely high and it is important to investigate the sepsis with appropriate experimental models. The most commonly used model for experimental sepsis is the cecal ligation and puncture (CLP) model. [6,7] Inflammation plays an important role in the etiology and prognosis of sepsis. With the release of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), the severity of the inflammatory response increases.[8,9] With cytokines and leukocyte activation, inflammatory responses are exacerbated, and organ damage occurs. The most important role in tissue damage is the releasing of oxidative molecules.[10] Because of the oxidative stress, tissue damage occurs due to the decrease of antioxidant molecules that arise from increased reactive oxygen species (ROS) and nitrogen.[11] An increase in ROS causes lipid and protein peroxidation to enhance malondialdehyde (MDA), the fatty acid peroxidation product.[12,13] Myeloperoxidase (MPO) is an indicator of neutrophils concentration in damaged tissues. [14] While the total antioxidant level (TAS) is used as an indicator of total antioxidant activity, total oxidant status (TOS) is a strong marker to determine total oxidant status. Oxidative stress index (OSI) is a value indicating the balance in the current oxidative status.[15,16]

Investigation of Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats