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High-Grade Gliomas are the most commonly encountered primary brain tumors in adults and Glioblastoma multiforme (GBM) is one of the most rapidly progressing and fatal tumor in high-grade gliomas.[1] Surgery plus chemotherapy and radiotherapy (RT) are the gold standard treatment of GBM.[2] Postoperative radiotherapy is usually administered with 2 Gy daily fractions in six weeks. Improvement in survival was achieved with chemotherapy added to radiotherapy; however, five-year survival is very low (9.8%).[3,4] In these patients with short survival expectation, a shorter duration of treatment has been considered, and hypofractionated RT schedules were studied. In a randomized study reported by Poland et al. 44 patients with GBM who were treated with three split courses of hypofractionated RT to a total dose of 50 Gy.[5] Patients with GBM treated with hypofractionated RT regimen, had a better prognosis in comparison to the conventionally fractionated group with the two-year survival rates being 23% and 10%, respectively. In elderly GBM patients treatment with a shorter hypofractionated radiotherapy course demonstrated similar survival and palliative benefit compared to a standard 6-week course (overall survival 5.6 versus 5.1 months, p=0.57) in the study reported by Roa et al.[6]

Hypofractionated Radiation Therapy With Temozolomide For Patients With Glioblastoma Multiforme Recursive Partitioning Analyzes Class V and VI