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Results: The sensitivity, specificity, and positive predictive values for keratinized lamellar cytoplasm and dense chromatin in SCC, and for flat sheets and nucleocytoplasmic polarity in AC were more than 60%. Immunohistochemical analysis revealed 60% sensitivity and 93% specificity for thyroid transcription factor 1 in AC. P63 and cytokeratin 5/6 had 73% and 64% sensitivity and 78% and 96% specificity, respectively, in SCC. The immunohistochemistry results of the cell blocks and the resection material demonstrated 94% conformity.

Histologic Subtyping of Lung Carcinomas: From The Targeted Therapy Perspective