English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives: The aim of this study was to retrospectively evaluate the efficacy and safety of lacosamide (200-300-400 mg/day) as adjunct treatment in patients with uncontrolled focal-onset seizures taking 2 or more antiepileptic drugs (AED). Methods: A retrospective review of the medical records of patients with uncontrolled focal epilepsy who received lacosamide as add-on therapy for at least 6 months was performed. Data collected and analyzed included demographic information, lacosamide dosing, concomitant AED therapy, and seizure activity in first and sixth months. Results: A total of 83 patients were evaluated. The mean percent reduction in seizure frequency per month was 38.98% in the first month and 33.22% in the sixth month. In all, 53% of the patients had a decrease in seizures of 50% or more in the first month, and 47% saw a similar decrease in the sixth month . The percentage of those taking a sodium channel blocking AED in addition to lacosamide was 97.6%. Doserelated adverse events reported included dizziness, nausea, diplopia, gastroenterological side effects, headache, itchy skin, and blurred vision. It was determined that all of the patients with drug-related side effects were taking a sodium channel blocking AED concomitantly with lacosamide. Conclusion: Adjuvant treatment with lacosamide reduced seizure frequency for patients with uncontrolled focal-onset seizures.

The Role Of Add-On Lacosamide Therapy In The Treatment Of Focal Onset Epilepsy