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Correspondence: Mehmet Hamdi Orum, Kahta State Hospital, Department of Psychiatry, 02100, Adiyaman Turkey E-mail: mhorum@hotmail.com Received: November 14, 2019; Revised: February 18, 2020; Accepted: March 24, 2020 ABSTRACT Objective: Various methods are used to determine a person’s opioid/marijuana status. However, more specific and sensitive markers are needed that are easily applicable and accessible. Complete blood count (CBC) is a convenient method to be used for this purpose. In this study, we investigated the relationship between CBC values – particularly monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) – and opioid/marijuana use disorder. Method: We compared CBC values of 56 male patients diagnosed with opioid use disorder (OUD), 56 male patients diagnosed with marijuana use disorder (MUD), and 56 healthy subjects. Results: The percentage of monocytes was significantly higher in the MUD group compared to the OUD group (p=0.010). The monocyte count was significantly different in the MUD group compared to the other two groups (p=0.018). MLR was significantly higher in the MUD group than in the OUD group (p=0.049). PLR was significantly different from the other two groups in the OUD group (p=0.038). In the MUD group, percentage of monocytes was declining with age (r=-0.474, p=0.011). The area under the receiver operating characteristic curve of the monocyte count value for MUD was 0.670. Conclusion: Measurements like lymphocyteand monocyte-related ratios in OUD and MUD can be important in monitoring and detecting the substance and for differentiating between acute and chronic conditions. In order to clarify the subject, further studies with fewer limitations are needed.

Monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio in opioid use disorder and marijuana use disorder