English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Correspondence: Mert Besenek, Dokuz Eylül University, School of Medicine, Department of Child and Adolescent Psychiatry, İzmir Turkey Phone: +90 464 213 04 91 E-mail: mbesenek1989@gmail.com Received: April 15, 2019; Revised: May 13, 2019; Accepted: June 13, 2019 ABSTRACT Objective: Given the shortage of studies done in this field, our aim was to distinguish offspring of bipolar parents between symptomatic and asymptomatic, then to compare neuroimaging findings between groups, thus assessing the early biomarker potential of neuroimaging techniques. Method: In this case-controlled study, we compared an asymptomatic high-risk group and a symptomatic high-risk group with a healthy control group. Diffusion tensor imaging (DTI) with region of interest (ROI) was used to analyze mean diffusivity (MD) and fractional anisotropy (FA) values in the superior longitudinal fasciculus (SLF) of the frontal cortex, the genu and splenium of the corpus callosum (CC), the cingulum bundle of the anterior cingulate cortex (CB-aCC), and the uncinate fasciculus (UF). Results: No differences were found between groups for FA and MD in the CC, SLF, and UF, but MD of the CB-aCC was significantly higher in the AHR and SHR groups than in healthy controls. Higher MD values found in the aCC of the high-risk groups may represent cellular damage in that region, regardless of symptomatic status. Conclusion: Results from this study may suggest candidates that could contribute to the neural underpinnings of a bipolar prodromal phase. Further longitudinal studies with larger sample sizes are needed to map the association of neural development and bipolar disorder-related psychopathology in at-risk youth.

Anterior cingulate cortex disconnectivity in high-risk offspring of bipolar patients: a preliminary DTI study