Open AccessThe Roles of Fibrosis Index Based on Four Factors and Aspartate Transaminase-to-Platelet Ratio Index Scoring Systems as an Alternative to Transient Elastography Liver Stiffness in Liver Fibrosis Staging in Human Immunodeficiency Virus and Hepatitis C Virus Co-Infected Patients
Author(s) -
Susanne O Ajao,
Dawn Roach,
Kok Hoe Chan,
Kundana Thimmanagari,
Ala Muhanna,
Monica Mutyala,
Saraswathi Lakasanni,
Jihad Slim
Publication year - 2021
Publication title -
gastroenterology research
Language(s) - English
Resource type - Journals
eISSN - 1918-2813
pISSN - 1918-2805
DOI - 10.14740/gr1377
Subject(s) - transient elastography , medicine , aspartate transaminase , alanine transaminase , liver biopsy , gastroenterology , hepatitis c virus , hepatitis c , liver disease , population , surgery , biopsy , immunology , virus , alkaline phosphatase , biochemistry , chemistry , environmental health , enzyme
Liver biopsy used to be the gold standard to assess liver fibrosis in patients infected with hepatitis C virus (HCV). Nonetheless, due to its invasive nature, techniques such as transient elastography liver stiffness (TE-LS), fibrosis index based on four factors (FIB-4) and aspartate transaminase-to-platelet ratio index (APRI) scores are currently being used. FIB-4 and APRI scores have the advantage of low cost and are readily available, compared with TE-LS. Herein, we evaluated the diagnostic performance of these scoring systems as compared to TE-LS in assessing liver fibrosis in patients with human immunodeficiency virus (HIV) and HCV co-infection.