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Introduction. 1,2,4-Triazole derivatives have already proven themselves to be compounds with low toxicity and high antimicrobial, antifungal, antiviral, hepatoprotective activity. The aim of work is to research the anti-tuberculosis activity of 5-(thiophen-2-ylmethyl)-4 H -1,2,4-triazoles-3-thiol on the bacteria strain M. bovis . Materials and methods. At the beginning of the experiment, the effect of the drug concentration and the pH of the medium on the growth rate of the culture at 37 °C was detected. M. bovis 100 passage was selected for this purpose, which was cultured at 37 °C with 5-(thiophen-2-ylmethyl)-4 H -1,2,4-triazole-3-thiol at the indicated concentrations in a thermostat for 3 months on medium with pH 6.5 (ten test tubes with each medicine concentration) and pH 7.1 (ten test tubes with each medicine concentration). M. bovis 100 passage was used as a control without the addition of 5-(thiophen-2-ylmethyl)-4 H -1,2,4-triazole-3-thiol to the medium. Results. The results of the experiment show that the effect of the drug at different concentrations on the medium with a pH 6.5 same with pH 7.1. Growth of pathogenic strain M. bovis 100 passages throughout the observation period (90 days) have been absence for all of the test (0.1 %, 0.5 % and 1.0 %) concentrations of 5-(thiophen-2-ylmethyl)-4 H -1,2,4-triazoles-3-thiol. Conclusion. It can be concluded that 0.1 %, 0.5 % and 1.0 % concentration of 5-(thiophen-2-ylmethyl)-4 H -1,2,4-triazole-3-thiol influence on the culture properties pathogenic strain M. bovis , which cultured on the medium with pH 6.5 and pH 7.1 at 37 °C, while holding back growth, having a tuberculostatic effect.

Anti-tuberculosis activity research of 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol