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Results. It was found that the incidence of mixed cryoglobulins in the blood of patients with CHC had a dependence on the degree of fibrosis of the liver. In the presence of liver fibrosis F 3–4 mixed cryoglobulins were found in 94.2 % versus 64.7 % of patients with stages of liver fibrosis F 12 (P < 0.01). In patients with stages of liver fibrosis F 3–4, the quantitative content of mixed cryoglobulins, RF-IgM and CIC was higher than those of patients with stages of liver fibrosis F 1–2. In patients with fibrosis in the liver F 3–4 cryoglobulinema incidence of vasculitis with formation of Meltzer’s triad was higher than in patients with liver fibrosis F 1–2 (19.2 % versus 2.9 %, P < 0.05). Content of mixed cryoglobulins correlated with the degree of fibrosis of the liver (r= +0.49, P < 0.01). A factor A3 was more often detected in patients with stage F 3–4, compared with patients with stage F 1–2 of fibrosis (81.5 % versus 19,2 %, P < 0.01).

The interaction of morphological changes in the liver with the development of extrahepatic manifestations in patients with chronic hepatitis C