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| Interferon-gamma (IFNγ) is associated with a number of autoimmune diseases, in addition IFNγ is a key cytokine involved mainly in the defense against intracellular. We aimed to examine the role of IFNγ gene +874 T/A polymorphism in T. gondii infection susceptibility among children with type 1 diabetes. This study included 107 children and adolescents with T1DM in addition to 95 healthy controls. We evaluated levels of anti-T. gondii Ig-G and IFNγ in the participants’ sera. All participants were also genotyped for IFNγ gene polymorphism at position +874T/A. Among the type 1 diabetic patients, 51 cases were positive for anti-Toxoplasma gondii IgG , while in controls were 40 individuals. In addition, no significant difference was detected as regard serum levels of IFNγ between the two groups. Moreover, no statistically significant differences were detected as regard the IFNγ gene +874 T/A polymorphism genotypes frequencies among different Toxoplasma gondii Ig-G seropositivity subgroups (p ˃0.05). The serum IFNγ levels were significantly higher among diabetic patients with IFNγ +874 (A/T) genotype and T allele than controls (p=0.01). Our results do not support a role of IFN-γ gene +874T/A polymorphism in the development of T1DM or susceptibility to Toxoplasma infection in patients with type 1 diabetes.

Interferon-Gamma +874 T/A Gene Polymorphism and Susceptibility to Toxoplasma Infection among Children with Type 1 Diabetes: A Possible Relationship