English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

| The enormous amount of viral species in nature arouses curiosity about not only their origin, but also forces their naming and organizing them into hierarchically arranged systematic units. The rapid evolution of viruses, in particular RNA viruses, has led to emergence of many new genotypes. The sequencing of whole genomes, genes or gene fragments is more and more commonly used for understanding epidemiology. Most accepted modern phylogenies are derived using sequences from individual homologous genes which may fail sometimes to construct a true phylogenetic tree. The first problem is that the evolutionary history of a particular gene is not necessarily the same as the evolutionary history of the virus in which it can be observed. This might be due to duplication and deletion, or even horizontal gene transfer between different viruses. Secondly, it is not always possible to find genes that are sufficiently conserved across all our viruses of interest to be successfully identified, and yet sufficiently diverged to be of use for phylogenetic analysis. One of the most pervasive challenges in molecular phylogenetics is the incongruence and discordance between phylogenies obtained using different data sets, such as individual genes. Whole genome based phylogenetic analysis has helped to characterize the novel viruses, uncover the population history of the disease, elucidate virus-host interactions, understanding of the evolutionary rates, monitoring gene reassortment, interspecies transmission between different viral strains and produce estimates of epidemiological parameters. In this review, we discussed efforts that have been made to infer phylogenies by consideration of the viruses at the genome level, rather than just individual genes.

Whole Genome Sequence Analysis of Viruses; Moving Beyond Single/Partial Gene Based Phylogenies in Context of Epidemiology and Genetic Evolution