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We previously reported the bioavailability enhancement of lipophilic Coenzyme Q10 (CoQ10) by complexing with  Cyclodextrin ( CD). Here, we report on its mechanism. Hydrophobic CoQ10 generally agglutinates but the dissociated CoQ10 from  CD was captured by bile acid to form nanometer molecular micelle without aggregation and therefore both solubility and bioavailability could be enhanced. Furthermore, we succeeded in the expansion of this finding to personal care field by the use of Dipotassium glycyrrhizate (GZK2) instead of bile acid. The skin absorptions of actives could be significantly enhanced by the combination of cosme-ceutical- CD complexes with GZK2.

A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing lipophilic bioactives with γ-Cyclodextrin