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Electrospun non-woven fiber mats of cyclodextrin (CD)-immobilized poly(vinyl alcohol) (PVA) could effectively block gene expression mediated by bacterial cell-to-cell communication, quorum sensing (QS). In Serratia marcescens AS-1 as one of the model opportunistic pathogens, N-acyl-L-homoserine lactone (AHL) activates production of antibiotic prodigiosin as a QS signal when the AHL concentration reaches a threshold associated with cell growth. By immersing CD-immobilized fiber mats in the culture broth of S. marcescens AS-1 at beginning of shaking culture, prodigiosin production was successfully intercepted to approximately 30% in the presence of only 0.13 wt% immobilized α-CD or 2-hydroxypropyl-β-CD. It suggested that AHL was almost maintained under the threshold concentration because of forming the inclusion complex with the immobilized CD. By immobilizing CDs on PVA, the inhibitory effects could be enhanced probably by increasing apparent stability constant for CD-AHL complex due to forming hydrogen bonds with hydroxyl groups of the PVA chains. Electrospinning of CD-immobilized PVA provides effective materials for QS inhibition due to trapping AHL signals associated with virulence factor expression in opportunistic pathogens.

transactions of the materials research society of japan

Inhibitory Effects of Quorum Sensing in &lt;i&gt;Serratia marcescens&lt;/i&gt; AS-1 by Electrospun Polyvinyl Alcohol Fibers Immobilized with Cyclodextrin