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Masahiko Nagaki, Kazuhiko Miyata, Jun Kawakami, Ryo Miyamoto, Yuji Maki*, Hiroshi Sagami**, and Tanetoshi Koyama** Graduate School of Science and Technology, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan *Department of Material and Biological Chemistry, Faculty of Science, Yamagata University, Kojirakawa-machi, Yamagata 990-8560, Japan **Institute of Multidisciplinary Research for Advanced Materials, Tohoku University Aoba-ku, Sendai, Miyagi 980-8577, Japan Fax: 81-172-39-3947, e-mail: nagaki@cc.hirosaki-u.ac.jp

Substrate specificities of wild- and mutated-type farnesyl diphosphate synthases with artificial substrate homologs