English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

There is close relationship between hypothyroidism and oxidative stress. In hypothyroidism,  lipid level, which is a potential target for oxidation, may be depressed by decreased free radical production. Our objective is to investigate the changes in sialic acid (SA) and oxidized-LDL (ox-LDL) levels in hypothyroid subjects with and without hyperlipidemia. Forty Wistar Albino rats were divided into 4 groups equally as follows: 1. Control group, 2. Hypothyroid group, 3. Hyperlipidemic group, and 4. Hyperlipidemic hypothyroid group. Thyroid and lipid parameters, ox-LDL and SA levels were determined in serum samples. Oxidized-LDL and SA were significantly higher in each group compared to the control group. Also hyperlipidemic hypothyroid group has increased lipid parameters, ox-LDL and SA levels compared to both hypothyroid and hyperlipidemic groups. Hypothyroidism accompanied by hyperlipidemia was observed to trigger the free radical oxidation. Changes in metabolic rate and increased lipid levels in serum may cause LDL oxidation, which in turn raises serum SA level. Serum SA level may be a marker of LDL oxidation. OZET Hipotiroidizm ile oksidatif stress birbiriyle yakindan ilgilidir. Hipotiroidizmde, oksidasyonun hedefi halindeki lipitlerin miktarindaki artis metabolizmanin baskilanmasi sebebiyle daha az radikal olusumu beklenebilir. Amacimiz hiperlipidemili ve hiperlipidemisiz hipotiroidili olgularin ve kontrollerin siyalik asit ve oksitlenmis LDL degisimlerini incelemektir. 40 adet Wistar Albino sican esit olarak 4 gruba ayrildi, gruplar: 1. Kontrol grubu, 2. Hipotiroid grubu, 3. Hiperlipidemik grup, 4. Hiperlipidemik hipotiroidi grubu. Alinan serum orneklerinde tiroid ve lipid parametreleri, okside LDL ve siyalik asit duzeylerine bakildi. Kontrol grubuna kiyasla hem hipotiroidi ve hem hiperlipidemi gruplarinda okside LDL ve siyalik asit seviyeleri artmistir. Ayrica, hiperlipidemik hipotiroidi grubunda, diger gruplarla kiyaslandiginda bu parametreler artmistir. Hipotiroidiye eklenmis hiperlipideminin, serbest radikal olusumunu tetikledigi gozlenmistir. Metabolizma hizindaki degisiklik ve oksidasyonun hedefi olan serum lipid seviyelerindeki artis, LDL oksidasyonuna ve dolayisiyla serum siyalik asit seviyesinin artisina  neden olabilir. Siyalik asit, LDL oksidasyonu icin bir belirtec olabilir.

THE FUNCTION OF SIALIC ACID AS A RADICAL SCAVENGER IN EXPERIMENTAL HYPOTHYROIDISM WITH AND WITHOUT HYPERLIPIDEMIA