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Interleukin-18 (IL-18) plays a critical role in immune response,contributing to the pathogenesis and pathophysiology of infectious diseases.Polymorphisms in the IL-18 genes are known to influence expression levels andmay be associated with outcome of infections. The objective of this study was todetermine whether the presence of IL-18 polymorphisms -607 A/C (rs1946518)was associated with tuberculosis disease. We investigated the functionalpolymorphism of IL-18 (rs1946518) in 174 patients with pulmonary tuberculosis(PTB) and 177 healthy subjects. Genotype analysis was done using tetra amplificationrefractory mutation system-PCR (T-ARMS-PCR). The allelic and genotypicfrequencies of the IL-18 polymorphism did not differ significantly between PTB andthe controls. Our finding suggests that IL-18 polymorphism (rs1946518) may notbe a risk factor for susceptibility to tuberculosis in a sample of Iranian population.Further studies are required to validate our findings.

Lack of Association between Interleukin-18 –607 C/A Gene Polymorphism and Pulmonary Tuberculosis in Zahedan, Southeast Iran