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Telah dilakukan penelitian tentang uji efektivitas kombinasi ekstrak kulit batang dan kulit buah manggis ( Gracinia mangostana L.) sebagai antibakteri Shigella dysenteriae dari bulan Maret sampai Mei 2011, untuk mengetahui konsentrasi efektif dari ekstrak kulit batang dan kulit buah manggis dalam menghambat pertumbuhan bakteri Shigella dysenteriae . Penelitian uji antibakteri ini menggunakan metode difusi cakram ( Kirby-Bauer ). Konsentrasi perlakuan yang diperoleh dari uji awal MIC digunakan untuk uji efektivitas kombinasi dari ekstrak kulit buah dan ekstrak kulit batang masing-masing 5,5%, 6,25%, 7%, 7,75%, 8,5%, dan 4,5%, 5,25%, 6%, 6,75%, 7,5%. Sebagai pembanding digunakan antibiotik kloramfenikol 50μg/ml. Dari hasil analisis keragaman dengan Rancangan Acak Lengkap berfaktor diperoleh bahwa pada setiap faktor konsentrasi perlakuan menunjukkan berbeda tidak nyata. Uji antibakteri dengan diameter zona bening yang paling efektif terdapat  pada perlakuan kombinasi konsentrasi esktrak kulit buah dan kulit batang manggis A2B1 6,25% dan 4,5% yaitu 5,66 mm dengan kategori daya hambat sedang (5-10 mm). Hasil zona bening baku pembanding kloramfenikol sebagai antibakteri Shigella dysenteriae yaitu 5,55 mm. A research on combined the effectiveness Test of combination  of tree bark and rind extract of Mangosteen ( Gracinia mangostana L.) as antibacteria on Shigella dysenteriae to know the effective concentration of tree bark and rind extract of Mangosteen in inhibiting the growth of Shigella dysenteriae had been conducted from March to May 2011. Research method used is disk diffusion ( Kirby-bauer ). The obtained concentration in preliminary test MIC which were used to exam combined effectiveness test of each tree bark and rind extract of mangosteen were 5,5 % ; 6,25 % ; 7 % ; 7,75 % ; 8,5 % and 4,5 % ; 5,25 % ; 6 % ; 6,75 % ; 7,5 %. Antibiotic Chloramphenicol 50 µg/ml was used as standard of comparison. Based on Diversity analysis by using factorial completely randomized design method acquired that each test concentration factor indicated not significantly different result. The most effective clear zone diameter of antibacterial test found in combination of 6,25% and 4,5% of tree bark and rind extract (A2B1) that was 5,66 mm as medium inhibition in category (5-10 mm). While the result of Chloramphenicol comparison clear zone as antibacterial was 5,55 mm.

UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT BATANG DAN KULIT BUAH MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIBAKTERI Shigella dysentriae