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Background : Diabetes Mellitus (DM) is a disease associated with pancreatic β cell damage and causes hyperglycemia Antioxidants were effective in reducing the state of hyperglycemia that was triggered by free radicals. Sarang semut contain s flavonoids and tannins that act as antioxidants. Objective : The p urpose to analyze the effectiveness of sarang semut stem extract as lowering blood glucose on diabetic white male Sprague Dawley rats . Method : True experimental with 30 rats which divided into five groups : negative control (DM + water ), positive control (DM+glibenklamid) and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200g BW, 180 mg/200g BW and 360/200g BW respectively . DM was induced by 65mg/kg BW Streptozotocin and 230 mg/kg BW Nicotinamide intraperitonealy . E xtract was given by sonde. The d ata was analy zed by Kruskall-Wallis and Mann-Whitney. Results : IC 50 value o f  sarang semut stem extract were 6,56-10,07 mg/ml in powder and 9,12-15,62 mg/ml whole. The average rats weight alteration on groups of negative control, positive control,  and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200g BW, 180 mg/200g BW and 360/200g BW before and after treatment were -7,60± -0,40; 25,80±0,51; 16,40±0,44; 17,20±1,28 dan 19,20±0,06 gram respectively (ρ=0,001). The average fasting blood glucose level on groups of negative control, positive control,  and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200g BW, 180 mg/200g BW and 360/200g BW before and after treatment were 3,33±2,42; -122,44±-0,51; -79,42±-11,38; -94,08±-11,97 and -134,66±-2,59 mg/dL respectively (ρ=0,001). Conclusion : T he IC 50­ value in sarang semut stem powder was higher than a whole form . Dose of 360 mg/200g BW lowered blood glucose better than 90 and 180 /200g BW dosage.

jurnal gizi indonesia

Efektivitas ekstrak umbi sarang semut (myrmecodia pendens merr.&amp; perry) sebagai penurun kadar glukosa darah tikus sprague dawley yang diabetes mellitus