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1 Letter Advice on Avoiding the Valley of Death: Insights from a 3Rs Model of Aversive and Emetic Compound Identification Robin S.B. Williams* and Paul L.R. Andrews Centre for Biomedical Sciences, School of Biological Sciences, Royal Hollow University of London, Egham, TW20 0EX, United Kingdom; Division of Biomedical Sciences, St George’s University of London, Tooting, London, SW17 0RE, United Kingdom

Advice on avoiding the Valley of Death: insights from a 3Rs model of aversive and emetic compound identification