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This article gives a brief summary about the current status of radiochemistry and radiopharmaceutical chemistry as related to the fac-[99mTc(OH2)3(CO)3]+ and fac-[99Tc(OH2)3(CO)3]+ synthon. Since the synthesis and availability of synthons or direct precursors for the labeling of biomolecules (and for the exploration of fundamental inorganic and organometallic chemistry) is a crucial prerequisite for developing new radiopharmaceuticals, some consideration about composition and characteristics of such complexes are discussed at thee beginning and their suitability is discussed. . Beside widely investigated basic and applied Tc chemistry in the oxidation state (V) with the [Tc=O]3+or [Tc=N]2+ moieties, the aforementioned [99(m)Tc(CO)3]+ and [99Tc(CO)3]+ core are new members in this group. Although its pressureless synthesis from organic solvents has been described about eight years ago, it is only recently that exploitation of its radiopharmaceutical potential could reasonably start owing to the availability of a routinely applicable kit. We will summarize basic coordination chemistry of the [99(m)Tc(CO)3]+ and [99Tc(CO)3]+ moieties as relevant for radiopharmaceutical purposes, focusing on some fundamental reactions in the context of low valent Tc chemistry. Due to its special properties, new research directions possible only through its very special physico-chemical properties will be emphasized as well.

The Facettes of [99TcCl3 (CO) 3]2- Chemistry and Its Application to Life Science