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Fentanyl is a pain reliever drug for hospital use mainly indicated as an anesthesia adjunct. Due to a complaint made by a hospital located in Sao Paulo, related to therapeutic failure of an injectable solution containing fentanyl citrate after use in anesthesia, samples of the product were collected for analysis by health services. The objective of this study was to perform physico-chemical tests on the samples, with priority to quantification and drug identification, using a high performance liquid chromatograph couppled with diode array detector. The two batches analyzed showed positive identification of fentanyl citrate and 97.30% of the drug content; these results were in accordance to recommended range by the product manufacturer. Thus, it was possible to exclude deviations in the drug content as the cause for therapeutic inefficacy, indicating the need for additional investigation and raising further discussion of the case.

INVESTIGAÇÃO DA SUSPEITA DE DESVIO DE QUALIDADE EM UMA SOLUÇÃO INJETÁVEL DE CITRATO DE FENTANILA