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Purpose: As there is growing evidence that the vitamin D status is correlated with breast cancer prognosis, in this study, we investigated the correlation between serum 1,25-dihydroxyvitamin D levels and the prognosis of patients with breast cancer in a Korean cohort. Methods: We performed a retrospective analysis of 436 Korean patients with breast cancer who were diagnosed between January 2000 and December 2008. According to the serum 1,25-dihydroxyvitamin D levels, the patients were divided into the following two groups: group 1 (<29.75 ng/ mL) and group 2 (≥29.75 ng/mL). Survival curves were obtained by using the Kaplan-Meier method. Univariate and multivariate analyses were also conducted to assess the independent prognostic significance of serum 1,25-dihydroxyvitamin D levels. Results: During a mean period of 84.66±29.29 months, 51 patients experienced tumor recurrence and 22 patients died. On survival analysis, group 1 showed poorer disease-free survival, especially for patients with luminal type breast cancer. Univariate and multivariate analyses showed that the 1,25-dihydroxyvitamin D status was a significant prognostic factor for disease-free survival, only in patients with luminal type breast cancer. Conclusion: The serum 1,25-dihydroxyvitamin D status can influence disease-free survival in Korean patients with breast cancer, particularly in those with luminal type breast cancer.

Correlation between Serum 1,25-Dihydroxyvitamin D Levels and Breast Cancer Prognosis in Korea