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Fabrication of Microneedle has attracted the great importance recently to reduce needle insertion pain and furthermore tissue trauma. LIGA, two photon photopolymerization, bulk lithography etc. are the various fabrication methods used for the development of these microneedles. However, despite the number of advantages of these methods, the use of microneedle is still less due to lesser throughput. Further these methods also incurred higher fabrication cost. This paper proposes a microfabrication method for polymer microneedles using sequential stereolithography and micromolding. The methodology includes preparing microneedle array using microstereolithography machine which is followed with preparing a micromold and then finally a microneedle array is made by using biocompatible, thermally curable polymer. Further, finite element analysis of microneedle array is carried out with an aim to verify the structural strength (to withstand resistance offered by skin during insertion) of the fabricated microneedle to withstand requirements for painless drug delivery.

Fabrication and Analysis of Three Dimensional Polymer Microneedle Array Potentially for Transdermal Drug Delivery