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The article presents the results of a study of phagocytic immunity chain in patients with CGP of I-II severity level on the background of enterobiasis, toxocariasis, giardiasis. The aim of this work was to study the nature of changes in the phagocytic immunity chain in patients with CGP of I-II severity level with parasitoses and patients with CGP without parasitoses. Studies were conducted on 540 patients with CGP, I-II severity level with parasitosis - (principle groups). The comparison group consisted of 90 CGP patients, I-II severity level without parasitosis, the control group – of 30 people without periodontal diseases and chronic diseases of other organs and systems. Phagocytic activity of neutrophils was assessed by their ability to absorb the S.aureus bacteria (strain 209), bactericidal capacity (BC) of phagocytes by the S. Nielsen method. Oxygen-dependent activity of phagocytes was studied in the spontaneous and induced zymosan HCT-test. Statistical processing of materials was made using mathematical statistical methods for the data analysis. There was established a reduction in patients with CGP of I-II severity level with parasitosis and in patients with CGP without parasitosis of the absorption and biocidal ability of peripheral blood neutrophils compared with healthy individuals. At I degree of CGP severity in patients without parasitosis, the number of cells, involved in phagocytosis (FI) was decreased on 13.7%, the number of microbes, absorbed by one cell (FN) on 17.3%, biocide – on 76%. As follows from the obtained data FI and FN in this group of patients did not differ from normal values significantly. In patients with CGP of I-II severity level without parasitosis all three indicators studied had a statistically significant difference. FI was reduced in comparison with the norm on 20.5%, FN – on 24.2%, BC – on 152%. In patients with CGP of I-II severity level with parasitosis the significant differences from the control group were observed both at the I degree of the disease, and at II severity level of the disease. At I degree of severity of the disease, reduction of FI in patients with parasitosis was 22.2  28.0%, FN – 32.8 – 39.7%, BC 158 – 170%, at II degree FI – 29.3 – 34.4 %, FF – 41.4 – 53.5%, BC – 238 – 264%. In patients with CGP of I-II severity level with parasitosis the significant differences compared with patients with CGP of I-II severity level without parasitosis were respectively related to the number of absorbed microbes by a single cell (FN) and biocidal capability of neutrophils (BC). Phagocytic index (PI) of patients with CGP of I-II severity level with parasitosis did not differ significantly from those in patients with CGP of I-II severity level respectively without parasitosis. In patients with CGP of I-II severity level with various forms of parasitosis is reduced as the induced red HCT test, as well as spontaneous HCT test. In patients with CGP of I-II severity level without parasitic, the spontaneous HCT test is increased in comparison with both infested patients, and the control group of individuals.

immunopatologiâ, allergologiâ, infektologiâ

The phagocytic activity of blood neutrophils in patients with chronic generalized periodontitis of I-II severity level on the background of parasitosis