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Se realizo un estudio comparativo entre la actividad antibacteriana de miel y cefalexina sobre una cepa de Escherichia coli y de miel y cefquinoma sobre una cepa de Staphylococcus aureus mediante ensayos de curva de muerte modificada. En todos los ensayos, la maxima actividad antibacteriana de la miel se observo a una dilucion del 50% v/v. Respecto de la eficacia comparativa entre la miel y los antibioticos, se observo que sobre E. coli , cefalexina logro una reduccion del conteo de bacterias viables compatible con un efecto bactericida (< 500 ufc/mL), mientras que la miel no logro superar este punto de corte. Lo opuesto se observo para S. aureus , donde la miel logro una reduccion del conteo de bacterias viables compatible con un efecto de erradicacion bacteriana (< 50 ufc/mL) respecto del efecto bactericida obtenido con cefquinoma (< 500 ufc/mL). Estos resultados preliminares, corroboran la necesidad de revalorar la actividad antibacteriana de productos naturales, cuya eficacia -aunque de manera empirica- ya era conocida desde la antiguedad y que fuera olvidada a partir de la aparicion de los antibioticos. SUMMARY . In vitro bactericidal activity of honey against Escherichia coli and Staphylococcus aureus. Comparison with the activity of cephalosporins. A comparative study was conducted between the antibacterial activity of honey and cephalexin against a strain of Escherichia coli and honey and cefquinome against a strain of Staphylococcus aureus by modified time-kill-curves essays. In all trials, the maximum antibacterial activity of honey was observed at a dilution of 50% v/v. Regarding the comparative efficacy between honey and antibiotics, it was observed that against E. coli , cephalexin achieved a reduction in viable bacteria count compatible with a bactericidal effect (<500 cfu/mL), while honey did not overcome this breakpoint. The opposite was observed for S. aureus , where honey achieved a reduction in the viable bacteria count compatible with a bacterial eradication effect (<50 cfu/mL) with respect to the bactericidal effect obtained with cefquinome (<500 cfu/mL). These preliminary results corroborate the need to revalue the antibacterial activity of natural products, whose efficacy - although empirically - was already known since antiquity and was forgotten after the appearance of antibiotics.

Actividad bactericida in vitro de miel sobre Escherichia coli y Staphylococcus aureus. Comparación con la actividad de cefalosporinas.