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Aim — in this study, we investigated whether polymorphisms Glu23Lys in  KCNJ11  are associated with Type 2 diabetes mellitus (T2DM) in the Kyrgyz population. Material and methods . We genotyped 287 Kyrgyz individuals. A case—control study was performed, including 178 patients with T2DM (female — 55, male — 123, average age 54±6,6) and 109 non-diabetes controls (female — 48, male — 61, average age 50±8,4). The genotypes of polymorphic position Glu23Lys of  KCNJ11  were determined by PCR-RFLP assay. Results . Genotypes Glu23Lys and Lys23Lys, containing the minor allele 23Lys, were more frequent in the group of type 2 diabetes (χ 2 =4,09;  p =0,043). The allele 23Lys of  KCNJ11  gene is associated with a high risk of developing type 2 diabetes in the Kyrgyz population [OR=1,46 (1,02—2,07);  p =0,036]. Homozygous genotype Glu23Glu and allele Glu23 reduces the risk of developing type 2 diabetes [OR=0,61 (0,37—0,99);  p =0,043 and OR=0,69 (0,48—0,98);  p =0,037], respectively). Conclusion . Polymorphisms Glu23Lys of  KCNJ11  gene are associated with the risk of Type 2 diabetes mellitus in the Kyrgyz Population according to the dominant and additive models of inheritance of the trait. Our results indicate that the allele 23Lys of  KCNJ11  gene confers an elevated risk for the development of Type 2 diabetes mellitus in the Kyrgyz population.

Polymorphisms Glu23Lys of KCNJ11 gene are associated with Type 2 diabetes in the Kyrgyz Population