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Purpose: To evaluate the effectiveness and tolerance of reirradiation with proton therapy (PT) in patients with recurrent gliomas. Patients and Methods: Between 2005 and 2012, 20 patients with recurrent gliomas were irradiated with proton therapy at the Indiana University Health Proton Therapy Center. Three had low-grade gliomas (LGGs, World Health Organization grade I/II), 4 had grade III, and 13 had glioblastoma (GBM, World Health Organization grade IV). The median time interval between initial radiation and reirradiation was 17.4, 62.8, and 15.3 months for LGG, grade III gliomas, and GBMs, respectively. The median dose delivered was 30, 59.4, and 54 Gy (RBE) for the low-grade, grade III, and grade IV tumors, respectively. Results: The median follow-up time from reirradiation was 8.3 months (range, 1.4 to 25.3), and 30% of the patients were alive at time of follow-up evaluation. Only 1 patient with an LGG had died. Median overall survival (OS) from the time of the original pathologic diagnosis ...

Reirradiation with Proton Therapy for Recurrent Gliomas