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Cutaneous side effects of capecitabine include hand foot syndrome which manifests as erythema, swelling and/or desquamation. We report a case on capecitabine treatment presenting with unusual hyperpigmentation of the tongue and skin of the palms and soles. This is a rare manifestation of capecitabine toxicity in darker skin patients. Clinicians and health care workers in oncology should be aware of this potential side effect.

Hyperpigmentation of the tongue, palms and soles: Rare side effect of capecitabine