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Pancreatic pseudocysts and peripancreatic fluid collections extending into the mediastinum are unusual. Endoscopically, intra-abdominal pseudocysts can be drained transmurally through the stomach or duodenum depending on the location. An endoscopic ultrasound–guided esophageal approach for mediastinal pseudocysts has not been reported commonly in the literature. We report a rare case of a large mediastinal pseudocyst that was drained through the distal esophagus with eventual complete resolution of symptoms and pseudocyst.

Endoscopic Cyst Esophagostomy Using a Lumen-Apposing Stent for a Large Mediastinal Pancreatic Pseudocyst Compressing the Left Atrium