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It was carried out histochemical study of placentas of healthy pregnant women and pregnant women with late severe preeclampsia. In the study we determined the expression of metalloproteinase type 9 and its inhibitor (TIMP-1). We found sufficient expression of TIMP-1 in the peripheral cytotrophoblast, villous and syncytial buds, which are washed by maternal blood. This explains the presence of paracrine regulation, restrictive cytotrophoblast invasion in the last months of pregnancy. For the first time we have obtained evidence of increased expression of tissue inhibitors of metalloproteinases (in particular TIMP-1) and the weakening of the expression of their substrates (MMPs) in severe preeclampsia by invasive cells, but not in placental tissue homogenates or invasive cells in culture (as previously shown in other studies).

medicinskij vestnik severnogo kavkaza

Immunohistochemical expression of matrix metalloproteinase -9 and tissue inhibitor of metalloproteinase-1 in placental tissue IN late severe preeclampsia