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BACKGROUND Hepatitis C Virus (HCV) infection is the commonest blood borne infection among haemodialysis patients. Despite reduction of Hepatitis C prevalence after recognition of the virus and testing of blood products, haemodialysis patients still comprise a high risk group. Hepatitis C Virus is detected on the basis of serology, liver function profile and molecular methods. Genotyping is an important tool in epidemiological study, pathogenesis and reaction to antiviral therapy. MATERIALS AND METHODS The haemodialysed patients with appropriate symptoms were tested for Hepatitis C Virus (HCV) infection, between July 1, 2015 and February 18, 2016. Blood was aseptically collected and processed for detection of Anti-HCV antibody by ELISA in Department of Microbiology, CMC and H, Ludhiana. Quantitative detection of HCV-RNA was done by Real Time Polymerase Chain Reaction (RTPCR) and if this was positive genotyping was done. RESULTS A total of 52 Chronic Renal Disease patients (39 male and 13 female patients) who underwent haemodialysis were tested for HCV RNA, out of which 10 (19.23%) came as positive. In 3 patients Genotyping has result of 2 patients with genotype 1 (66.67%) and 1 patient with genotype 4 (33.33%). Patients with Chronic Renal Disease with HCV infection had received more number of dialysis sessions (biweekly) as compared to those without HCV infection. Currently, Hepatitis C virus is most frequently found in patients with Chronic Renal Disease patients undergoing haemodialysis. The diagnosis of HCV is confirmed by detection of HCV-RNA by Polymerase Chain Reaction. CONCLUSION In the present study, it was seen that duration and frequency of dialysis is significantly longer among HCV positive patients as compared to HCV negative patients. Attention should be given to strict adherence to infection control measures in dialysis setting.

journal of evolution of medical and dental sciences

PREVALENCE AND DETECTION OF GENOTYPE OF HEPATITIS C VIRUS IN CHRONIC RENAL DISEASE PATIENTS UNDERGOING HAEMODIALYSIS IN TERTIARY CARE HOSPITAL IN PUNJAB