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Platinum complexes have attracted considerable scientific and clinic interest, they are amongst the most widely used anticancer agents. The square planar compound cis-dichlorodiamine platinum (cis-DDP, cis-platin) was recognized as an active substance in antitumor treatment [1]. The anticancer drug cis-platin reacts with DNA in the nucleus of a cell, this prevents the cell from dividing. Normal cells can repair the DNA damage, but cancer cells are unable to repair the damage and soon die, so it is supposed to exert their antitumor activity by impairing the DNA normal functions [2]. Since the discovery of this activity, much progress has been made in understanding its mode of action and details of the mechanism leading to antitumor activity are now well established [3]. Due to the chemotherapeutic importance of cis-platin and to improve clinical effectiveness of the Pt-based chemotherapy, continuing search for the novel Pt drugs is inevitable and several complexes with nucleobases, which have revealed a high anticancer activity in vitro as compared to cis-platin, were synthesized from the parent or related compounds [4-8]. The discovery of the antitumor activity of cis-platin has simulated great interest in platinum-nucleic acid interactions [4]. The coordination of cis-platin to DNA purine bases represents a frequent topic of many recent papers. Despite the vast body of research on platinum drugs; their mechanisms of action and a trans Effect of Amino-Chloro-Platinum Complexes and the Reaction of Cisplatin with Guanine: A Theoretical Study