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Dapagliflozin (DAPA) belongs to a new class of oral antidiabetic drugs, called sodium glucose co-transporter 2 (SLGT2) inhibitors. Inhibiting SGLT2, which have a key role in the reabsorption of glucose in the kidney, has been proposed as a novel therapeutic strategy for diabetes. Genetic mutations in the kidney-specific SGLT2 isoforms that results in benign renal glucoria. Hence it indicates that elevating renal glucose excretion by supressing SGLT2 can reduce plasma glucose level as well as weight [1,2]. Dapagliflozin was approved by the FDA on 2014, Jan 08. Dapagliflozin is not recommended for patients with diabetes mellitus type 1 or for the treatment of diabetes ketoacidosis. Dapagliflozin is used for the adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise [3,4]. It is chemically known as, (2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]-phenyl}-6-(hydroxylmethyl)oxane-3,4,5-triol (Fig. 1). The molecular formula is C21H25O6Cl and molecular weight is 408.873. Dapagliflozin is stable under thermal, photo and neutral hydrolysis stress conditions but it is liable to undergo a degraA Validated Stability Indicating High Performance Thin Layered Chromatographic Method for the Analysis of Dapagliflozin in Bulk Drug and Marketed Tablet Formulation

asian journal of chemistry/asian journal of chemistry

A Validated Stability Indicating High Performance Thin Layered Chromatographic Method for the Analysis of Dapagliflozin in Bulk Drug and Marketed Tablet Formulation