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Phase transfer was used to catalyze nucleophilic aromatic substitution by Makosza and other [1-3]. Zoltewicz and others [4-7] have given a good early review of various methods and compared with other techniques that make use of polar solvents, transition metals and monoelectron transfers. In general, phase transfer catalysis (PTC) can be used for heteroaromatic SN reactions [8-11]. Chloro group present at position 2 and 4 in pyrimidine has been found reactive towards SN reactions with variety of nucleophilic reagents [12,13]. Nucleophilic displacements under phase transfer catalysis in fused pyrimidines have also been reported [14-16]. C-O coupling producing ether linkage (O-alkylation, O-arylation) is an important example of SN reaction. Isopropylidine glycerol moiety was known to impart remarkable biological activities [17-29]. In addition pyrimidine and fused pyrimidines with glyceryl moiety showing the pharmaceutical significance have been reported [30,31]. Synthesis of pyrazolopyrimidine having isopropylidene moiety are less reported [31]. Incorporation of phase transfer catalysis with Williamson ether synthesis provided a smoother and convenient path for ether formation. Few cases for heteroaromatic SN reactions employing alkoxide ions under phase transfer catalysis in A Rapid Phase Transfer Catalyzed Heteroarylation by C-O Coupling and Ring Opening of Isopropylidene Glycerol in Synthesis of (Pyrazolopyrimidin-4-yloxy)propane-1,2-diols

asian journal of chemistry/asian journal of chemistry

A Rapid Phase Transfer Catalyzed Heteroarylation by C-O Coupling and Ring Opening of Isopropylidene Glycerol in Synthesis of (Pyrazolopyrimidin-4-yloxy)propane-1,2-diols