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The protection of carbonyl groups plays an important role in drug design chemistry. The most common method for the preparation of Mannich bases are the reaction of aldehydes with active hydrogen containing amide moieties such as semicarbazide, thiosemicarbazide and 4,4-difluorocyclohexane carboxylic acid hydrazide in the presence of acid or base as catalyst with secondary amine [1-5]. The examples of clinically useful Mannich bases which consist of amino alkyl chain are cocaine, fluoxetine, atropine, ethacrynic acid, procyclidine and so forth. Mannich bases also known to play a vital role in the development of synthetic pharmaceutical chemistry. Mannich reactions are widely used for the construction of nitrogen containing compounds. These bases have important biological applications such as antifungal [6], antimicrobial [7-13], anticonvulsant [14,15], antitumor [16], antiepileptic activity [17], anti-inflammatory, analgesic [18], antimalarial [19] and antioxidant activity [20].

Potent Antimicrobial Agents of 8-Aza-bicyclo[3.2.1]octyl hydrazide Derivatives: Synthesis and Biological Evaluation