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Knoevenagel condensation is an important reaction in organic chemistry by which carbon-carbon double bond is formed. One of the product ethyl α-cyanocinnamates is used as an important intermediate for the synthesis of different pharmaceutically important organic compounds and also has application in making paper, dyes, fibers, plastics etc. [1]. Other product 5-arylidene derivatives of 4-thiazolidinones are well known in the pharmaceutical industry and have been shown a broad spectrum of biological activities including antiinflammatory [2a], antibacterial [2b], antiviral [2c], antimicrobial [2d], antifungal [2e] and possess aldose reductase inhibitors [2f], antidiabetic activity [2g-k]. A number of synthetic strategies have been developed for the Knoevengel condensation of aromatic aldehydes and ethyl cyanoacetate. This reaction is catalyzed by organic bases or with variety of catalyst like zeolites [3], AlPO4-Al2O3 [4], LaCl3·H2O [5], I2/K2CO3 [6], CTMAB [7], TEBA [8], NH4OAcBasic alumina [9], H3PW12O40 [10], NaF and LiCl [11], MgBr2· OEt2 [12], TiCl4/Base [13], MgO and ZnO [14], ZnCl2 [15], lipase as a biocatalyst [16], etc. The synthesis of 5-arylidene2,4-thiazolidinediones such as sodium acetate in acetic acid under reflux conditions [17], microwave irradiation [18], piperidine in ethanol [19a], piperidinium acetate in toluene under reflux conditions [19b], piperidinium acetate in DMF under microwave irradiation [20], glycine and sodium carbonate in H2O under reflux conditions [21], grinding with ammonium acetate in the absence of solvents [22], alum in H2O [23], Baker’s yeast [24], KF-Al2O3 under microwave irradiation [25], glycine under microwave irradiation [26], polyethylene glycol-300 Microwave Assisted Urea-Acetic Acid Catalyzed Knoevenagel Condensation of Ethyl Cyanoacetate and 1,3-Thiazolidine-2,4-dione with Aromatic Aldehydes under Solvent Free Condition

asian journal of chemistry/asian journal of chemistry

Microwave Assisted Urea-Acetic Acid Catalyzed Knoevenagel Condensation of Ethyl Cyanoacetate and 1,3-Thiazolidine-2,4-dione with Aromatic Aldehydes under Solvent Free Condition