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Atropine sulfate monohydrate (ASM, Fig. 1) is pharmaceutical formulation that is one of the World Health Organization’s list of essential medicines. Atropine itself is a naturally occurring tropane alkaloid with chemical structure similar to that of cocaine. Plants of the family Solanaceae that includes Atropa belladonna, Datura stramonium and Mandragora officinarum are the major natural sources of the alkaloid. Atropine serves as a drug with a wide variety of effects. It is a competitive antagonist of the muscarinic acetylcholine receptors, hence its major effects are on the parasympathetic nervous system. As an anticholinergic drug (parasympatholytic) it is considered a nonselective muscarinic acetylcholinergic antagonist. Consequently, its main medical uses are based on these potent biological properties. Since it blocks the action of the vagus nerve, atropine is used in resuscitation procedures. Additionally, atropine mixed with pralidoxime chloride (2-PAM chloride) is used as an antidote for poisoning by organophosphate insecticides and nerve gases, such as Tabun (GA), Sarin (GB), Soman (GD) and VX. Atropine has also several medical applications that include ophthalmic uses as therapeutic mydriatic and in slowing the progression of myopia in children . As much as it is crucially important to understand this kind of physiological activity, atropine interactions with common chemical reagents are still lacking. Oxidation of atropine by Kinetics of Oxidation of Atropine by Alkaline KMnO4 in Aqueous Solutions