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Some novel 1,3,4-oxdiazole derivatives bearing benz imidazole nucleus were synthesized and their invitro anti-inflammatory and antioxidant activity by inhi bit on of protein denaturation screening, 2, 2-Diph enyl-1Picryl Hydrazide screening methods respectively. Th e compound 7.XX and 7.XXIX were found to be highly active in low concentration and compounds 7.VIII, 7.IX, 7.X, 7.XIX, 7.XXII, 7. XXIV and 7.XXV were found to be moderately active at higher concentration as compar ed to ascorbic acid in 2, 2-diphenyl-1-picryl hydra zide method. In-vitro anti-inflammatory by inhibition of protein denatur ation method the compounds 7.VIII, 7.XX , 7.XXII and 7.XXIX were found to be highly active in low concentratio n and compounds 7.IX, 7.X, 7.XIX, 7. XXIV, 7.XXV and 7.XXXIII were found to be moderately active at higher conce ntration as compared to diclofenac sodium.

asian journal of chemistry/asian journal of chemistry

Design, Synthesis of Some Novel Thiazolidin-4-one Derivatives Bearing Benzimidazole Nucleus and Biological Evaluation of their Possible in vitro Antiinflammatory as Cyclooxygenase Inhibitors and Antioxidant Activity