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Jensen Lee Logan Instruments Corp. www.loganinstruments.com Logan Instruments Corp. was a late entrant into the dissolution tester manufacturing market. However, Logan had a large part in helping the industry grow. Automation, innovative concept design, and new equipment helped the industry flourish. Logan Instruments Corp. was the first dissolution tester manufacturer to create the 8-position dissolution tester for automation in the U.S. market. The 8-position automated version consists of auto-lift, auto-sampling, and auto-dropping mechanisms via RS232 cable. Being user-friendly, the delivery head and sampling manifold can be moved up and down easily by pressing buttons or through a PC. For automated UV analysis, Logan’s 8-position dissolution tester has six sample vessels, a blank, and a standard. The blank and standard vessels can also be used as preheated media replacement for automatic sampling systems. As the economic and production climate changed in the pharmaceutical industry, Logan created a 12-position dissolution tester. This unit helps customers in reducing their budget when a lab purchases one unit instead of two separate units, which also means less maintenance. Most of the generic drug companies need to mimic name-brand drugs by developing formulations. What’s the best way to compare dissolution data side by side? The 12-position bath is perfect for this application. Logan is currently still the only U.S. manufacturer of this type of dissolution bath. Continuing to be on the forefront of innovation in the dissolution industry, Logan developed the MDS-600 Media Delivery System and AVC-100 Automated Vessel Cleaner to reduce the downtime between dissolution tests. The MDS-600, which has been marketed since 1990, is still available with upgraded models that have current advancements. By its impeccable design, this unit can transfer six channels of precise, degassed, pre-heated media into six dissolution vessels simultaneously. With the success of the MDS, Logan introduced yet another first that makes the vessel cleaning process easy. The AVC-100 Automated Vessel Cleaner was introduced to wash the vessels while still in the dissolution tester; this helps limit the number of broken vessels. A vessel-cleaning method helps scientists to validate the cleanness of dissolution vessels. Both the MDS and AVC have increased the efficiency of the dissolution industry. Looking forward, Logan pushed the limits by developing yet another new instrumentation, the Logan DISSO III-7 that combines both USP 3 and USP 7 testing methods, again for ease of operation and saving lab space. This instrument only needs to input the stroke length from USP 3 testing method to USP 7. The USP 3 method could be used for controlled-release drugs, which is to test drugs that dissolve within the GI tract. The drug industry has improved through innovation and discoveries, so Logan has adapted to this process. Now drugs can be administered through the skin as well as implanted into the body. The USP 7 method can be used to test implants dissolving within the bloodstream and for quality control of transdermal patches. With the knowledge of dissolution testing, Logan has crossed over into other fields in dissolution studies. Around 1995, Logan entered the transdermal field. Logan has taken the idea of drug testing through the skin with a Franz Cell to a new level. To purge the bubbles between membrane/skin and media has been a tedious job. With dynamic features, Logan’s instrumentation provides a bubble-free system. In addition, Logan has automated this testing with several components that can run methods continuously for days as skin penetration can be administered over long periods of time. Within recent years, Logan has engineered two product lines to satisfy these testing needs and has become the world leader in transdermal and stent/implant drug testing instrumentation.

Celebration of Twenty Years from Dissolution Tester Equipment Manufacturers and Other Providers of Dissolution Related Services