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Most current dissolution procedures require samples to be withdrawn from the vessel, the exception being when the concentration is determined in situ with fiber optics. No matter whether the sample is withdrawn manually or automatically,effective filters are necessary to prepare the sample for analysis;otherwise,undissolved material from the medium could influence the results. All of the filter materials available on the market for dissolution testing may not be equally suitable for this task. For example, it is important that filter materials should have little or no tendency to adsorb the drug,since adsorption to the filter will result in out-of-specification results. The aim of this study was to examine drug adsorption to typical filter materials under a variety of dissolution test conditions. In addition,the influence of discarding the first 2 ml of the sample on adsorption to the filter was examined. Four different filter materials (nylon,cellulose acetate,regenerated cellulose and glass fiber) were tested with three model drugs:hydrochlorothiazide (highly water soluble), griseofulvin (poorly water soluble) and propranolol hydrochloride (cationic,highly water soluble) under various conditions. These conditions consisted of three dissolution media commonly used in USP dissolution testing and covered a pH range from pH 1.2 to pH 6.8.

Comparison of the Adsorption of Several Drugs to Typical Filter Materials